Studies in the Imidazole Series. 100. Synthesis of Derivatives of Imidazo [1, 2-a] pyrimidine from 2-Aminopyrimidines, Methyl Aryl Ketones, and Halogens
…, IA Mazur, GK Rogul'chenko, EV Aleksandrova…
Index: Kochergin; Mazur; Rogul'chenko; Aleksandrova; Mandrichenko Chemistry of Heterocyclic Compounds, 2000 , vol. 36, # 12 p. 1437 - 1440
Full Text: HTML
Citation Number: 1
Abstract
Abstract We have synthesized imidazo [1, 2-a] pyrimidine derivatives by reaction of 2- aminopyrimidines with methyl aryl ketones and halogens (bromine, iodine). Using bromine leads to formation of 6-bromo-and 3, 6-dibromo-substituted 2-arylimidazo [1, 2-a] pyrimidines.
Related Articles:
Synthesis of 2-arylimidazo [1, 2-a] pyrimidines by the Chichibabin synthesis in ionic liquids
[Xu, Danqian; Liu, Baoyou; Zheng, Mei Journal of Chemical Research - Part S, 2003 , # 10 p. 645 - 647]
[Aggarwal, Ranjana; Sumran, Garima Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 12 p. 2690 - 2695]