The Catalytic Asymmetric α??Benzylation of Aldehydes
…, A Lee, M Leutzsch, S Chandra Pan…
Index: List, Benjamin; Coric, Ilija; Grygorenko, Oleksandr O.; Kaib, Philip S. J.; Komarov, Igor; Lee, Anna; Leutzsch, Markus; Chandra Pan, Subhas; Tymtsunik, Andrey V.; Van Gemmeren, Manuel Angewandte Chemie - International Edition, 2014 , vol. 53, # 1 p. 282 - 285 Angew. Chem., 2014 , vol. 126, # 1 p. 286 - 289,4
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Citation Number: 25
Abstract
Abstract The first aminocatalyzed α-alkylation of α-branched aldehydes with benzyl bromides as alkylating agents has been developed. Using a sterically demanding proline derived catalyst, racemic α-branched aldehydes are reacted with alkylating agents in a DYKAT process to give the corresponding α-alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities.
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