Tetrahydro??1, 5??benzoxazepines and tetrahydro??1H??1, 5??benzodiazepines by a tandem reduction??reductive amination reaction
RA Bunce, CL Smith, JR Lewis
Index: Bunce, Richard A.; Smith, Christopher L.; Lewis, Jason R. Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 6 p. 963 - 970
Full Text: HTML
Citation Number: 6
Abstract
Abstract A tandem reduction-reductive amination reaction has been applied to the synthesis of (±)-4-alkyl-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepines and (±)-4-alkyl-1-benzoyl-2, 3, 4, 5- tetrahydro-1H-1, 5-benzodiazepines. The nitro aldehydes and ketones required for 1, 5- benzoxazepine ring closures were prepared by nucleophilic aromatic substitution of the alkoxides from several 3-buten-1-ol derivatives with 2-fluoro-1-nitrobenzene followed by ...
Related Articles:
Generalization of the Benzotriazole-Mediated Introduction of N-Substituents into Amides
[Katritzky, Alan R.; Ignatchenko, Alexey V.; Lang, Hengyuan Journal of Organic Chemistry, 1995 , vol. 60, # 13 p. 4002 - 4005]
[Padwa; Austin; Price; Weingarten Tetrahedron, 1996 , vol. 52, # 9 p. 3247 - 3260]
[Hoffman, Robert V.; Nayyar, Naresh K. Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3530 - 3539]
[Hoffman, Robert V.; Nayyar, Naresh K. Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3530 - 3539]
The oxidative dealkylation of tertiary amides: mechanistic aspects
[Iley, Jim; Tolando, Roberto Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 11 p. 2328 - 2336]