Artificial allosteric receptors for nucleotide bases and alkali-metal cations

M Inouye, T Konishi, K Isagawa

Index: Inouye, Masahiko; Konishi, Takashi; Isagawa, Kakuzo Journal of the American Chemical Society, 1993 , vol. 115, # 18 p. 8091 - 8095

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Citation Number: 46

Abstract

Abstract: New allosteric thymine receptors, 2, 6-diamidopyridine derivatives tethered to an anthracene ring by a polyoxyethylene chain, were synthesized. In these receptors, binding of 1-butylthymine was enhanced by a factor of 4-6 by recognition of sodium cations, and the changes in the electron density of the anthracene ring were found to have influence on the allosterism by through-space interaction. The anthracene-linked diamidopyridines ...