Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl) quinolin-4-amines, a new class of anti-HIV-1 agents

L Strekowski, JL Mokrosz, VA Honkan…

Index: Strekowski; Mokrosz; Honkan; Czarny; Cegla; Wydra; Patterson; Schinazi Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1739 - 1746

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Citation Number: 133

Abstract

53-56 weak for the thio derivatives. 2 A working hypothesis was formulated that the increased electron density at the ring nitrogen atoms, due to'the conjugation, has a favorable effect on the anti-HIV-1 activity. This increased electron density may stabilize a hydrogen- bond complex of the active molecule with a biological receptor, possibly the viral