Au-Catalyzed Piperidine Synthesis via Tandem Acyloxy Migration/Intramolecular [3+ 2] Cycloaddition of Enynyl Esters

H Zheng, X Huo, C Zhao, P Jing, J Yang, B Fang…

Index: Zheng, Huaiji; Huo, Xing; Zhao, Changgui; Jing, Peng; Yang, Juan; Fang, Bowen; She, Xuegong Organic Letters, 2011 , vol. 13, # 24 p. 6448 - 6451

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Citation Number: 21

Abstract

An Au-catalyzed tandem protocol involving enynyl ester isomerization and subsequent intramolecular [3+ 2] cyclization has been developed. This strategy provides an efficient approach for the synthesis of polyfunctional piperidines, which are subunits of many bioactive molecules.

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