Tetrahedron

Synthetic models for the transition metal binding site of bleomycin. Remarkable improvement of dioxygen activating capability

A Kittaka, Y Sugano, M Otsuka, M Ohno

Index: Kittaka, Atsushi; Sugano, Yuichi; Otsuka, Masami; Ohno, Masaji Tetrahedron, 1988 , vol. 44, # 10 p. 2811 - 2820

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Citation Number: 37

Abstract

Model compounds for the metal binding site of bleomycin with a CH2 CONH2 group (PYML- 3) or atert-butyl group (PYML-4) as steric environmental factors are synthesized. These exhibit metal binding properties similar to those of bleomycin. In particular, PYML-4 shows oxygen activation up to 71% of that of bleomycin.