The Synthesis and Preferred Conformation of Pyridoyl Urea and Analogous Derivatives: Preparation of a Folate Analogue

S Masiero, F Fini, G Gottarelli, GP Spada

Index: Masiero, Stefano; Fini, Federico; Gottarelli, Giovanni; Spada, Gian Piero Journal of Chemical Research, Miniprint, 1998 , # 10 p. 2736 - 2753

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Abstract

We are interested in pyridoyl urea and analogous derivatives as monocyclic models of guanine and pterine.1 A literature search revealed a scarcity of data on these unsubstituted acylurea derivatives and, in particular, a dearth of synthetic work.9a,b We have, therefore, tried a few straightforward synthetic pathways to easily obtain the desired derivatives from simple precursors (Scheme 1). ... The methyl ester gave the most encouraging results; specifically, when reacted with ...