An efficient synthesis of chrysin
M Liu, J Zhang, J Yang, B Yang…
Index: Liu, Man; Zhang, Ji; Yang, Jian; Yang, Bo; Cui, Wei Journal of Chemical Research, 2014 , vol. 38, # 3 p. 134 - 136
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Citation Number: 5
Abstract
Two routes for the synthesis of the flavones chrysin are described. In the first 1, 3, 5- trimethoxybenzene was converted to 2-hydroxy-4, 6-dimethoxyacetophenone and then by condensation with benzaldehyde to 2′-hydroxy-4′, 6′-dimethoxychalcone. The latter was cyclised with iodine and demethylated with pyridine hydrochloride to form chrysin in 53% overall yield. In the second route, 1, 3, 5-trimethoxybenzene was acylated with ...
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