Synthesis, and biological evaluation of 2-(4-aminophenyl) benzothiazole derivatives as photosensitizing agents

…, YK Chen, CC Liao, HS Yu, YM Tsai, SM Huang…

Index: Hu, Wan-Ping; Chen, Yin-Kai; Liao, Chao-Cheng; Yu, Hsin-Su; Tsai, Yi-Min; Huang, Shu-Mei; Tsai, Feng-Yuan; Shen, Ho-Chuan; Chang, Long-Sen; Wang, Jeh-Jeng Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 16 p. 6197 - 6207

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Citation Number: 50

Abstract

Photodynamic therapy (PDT) employing exogenous photosensitizers is currently being approved for treatment of basal cell carcinoma (BCC). 2-(4-Aminophenyl) benzothiazoles (6) consist of chromophoric structure and absorb light in the UVA (315–400nm). These results encouraged us to design and synthesize a diversity of 2-phenylbenzothiazoles (6). Studies on the apoptotic mechanism involved in photosensitive effects induced by UVA-activated ...