Tetrahedron

Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki–Miyaura cross-coupling reactions

G Bort, MSI Veitía, C Ferroud

Index: Bort, Guillaume; Sylla-Iyarreta Veitia, Maite; Ferroud, Clotilde Tetrahedron, 2013 , vol. 69, # 35 p. 7345 - 7353

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Citation Number: 5

Abstract

Abstract In positron emission tomography [11 C] PIB, Pittsburgh Compound-B, is currently the most widely used radiopharmaceutical for the early diagnosis of Alzheimer's disease. Synthetic routes for the preparation of the precursor of [11 C] PIB are reported in the literature. These strategies require multiple steps and the use of protecting groups. This paper describes a simple one-step synthesis of the precursor of [11 C] PIB through a ...