Indium??Catalyzed Cycloisomerization of ω??Alkynyl?螃漫?ketoesters into Six??to Fifteen??Membered Rings

…, K Endo, M Nakamura, E Nakamura

Index: Tsuji, Hayato; Yamagata, Ken-Ichi; Itoh, Yoshimitsu; Endo, Kohei; Nakamura, Masaharu; Nakamura, Eiichi Angewandte Chemie - International Edition, 2007 , vol. 46, # 42 p. 8060 - 8062

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Citation Number: 63

Abstract

The ene reaction between an enol and an alkyne is an established synthetic reaction with respect to its five-membered-ring-forming variant, known as the Conia reaction.[1, 2] Recent reports on transition-metal catalysis have described several examples of the extension of the reaction to six-and seven-membered carbocycles,[2a, f, i, 3] yet it is entirely unknown whether or not the reaction is applicable to the synthesis of larger rings. Herein, we report ...