New class of potent antitumor acylhydrazone derivatives containing furan

…, Y Li, Y Ling, J Huang, J Cui, R Wang, X Yang

Index: Cui, Zining; Li, Ying; Ling, Yun; Huang, Juan; Cui, Jingrong; Wang, Ruiqing; Yang, Xinling European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5576 - 5584

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Citation Number: 76

Abstract

A pair of chemical isomeric structures of N-acylhydrazone compounds I and II were designed and synthesized. The reaction was carried out with high diastereoselectivity to obtain one configurational isomer in excellent yields. The exact configuration and conformation of IIa and IIe were confirmed by the X-ray single crystal diffraction. The antitumor bioassay revealed that some compounds exhibited excellent activity against the ...