Metalloform-selective inhibition: synthesis and structure–activity analysis of Mn (II)-form-selective inhibitors of Escherichia coli methionine aminopeptidase

QQ Huang, M Huang, FJ Nan, QZ Ye

Index: Huang, Qing-Qing; Huang, Min; Nan, Fa-Jun; Ye, Qi-Zhuang Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 24 p. 5386 - 5391

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Citation Number: 27

Abstract

Methionine aminopeptidase (MetAP) is a promising target for development of novel antibacterial, antifungal and anticancer agents. However, its physiologically relevant metal ion remains to be defined, and its inhibitors need to inhibit the in vivo metalloform. Based on the Mn (II)-form-selective inhibitors discovered by high throughput screening as leads, a series of analogs of 5-phenylfuran-2-carboxylic acid was prepared and subsequently ...

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