Influence of bulky substituents on histamine H3 receptor agonist/antagonist properties
…, JC Schwartz, W Schunack, H Stark
Index: Sasse, Astrid; Stark, Holger; Reidemeister, Sibylle; Huels, Annette; Elz, Sigurd; Ligneau, Xavier; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4269 - 4274
Full Text: HTML
Citation Number: 22
Abstract
Novel derivatives of 3-(1 H-imidazol-4-yl) propanol were designed on the basis of lead compounds belonging to the carbamate or ether series possessing (partial) agonist properties on screening assays of the histamine H3 receptor. One pair of enantiomers in the series of α-methyl-branched chiral carbamates was stereoselectively prepared in high optical yields. Enantiomeric purity was checked by Mosher amide derivatives of ...
Related Articles:
[Reck, Reinhard; Jochims, Johannes C. Chemische Berichte, 1982 , vol. 115, # 3 p. 860 - 870]
Structure-based design of novel, urea-containing FKBP12 inhibitors
[Dragovich, Peter S.; Barker, John E.; French, Judy; Imbacuan, Michael; Kalish, Vincent J.; Kissinger, Charles R.; Knighton, Daniel R.; Lewis, Cristina T.; Moomaw, Ellen W.; Parge, Hans E.; Pelletier, Laura A. K.; Prins, Thomas J.; Showalter, Richard E.; Tatlock, John H.; Tucker, Kathleen D.; Villafranca, J. Ernest Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1872 - 1884]
Infrared and Raman spectra and vibrational assignment of methylene cyclopropane-h 6 and-d 6
[Schaumann,E. et al. Chemische Berichte, 1978 , vol. 111, p. 1475 - 1485]
Infrared and Raman spectra and vibrational assignment of methylene cyclopropane-h 6 and-d 6
[Schaumann,E. et al. Chemische Berichte, 1978 , vol. 111, p. 1475 - 1485]