Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: The discovery of 4-[4-(2-adamantylcarbamoyl)-5- …

JS Scott, J deSchoolmeester, E Kilgour…

Index: Reck, Reinhard; Jochims, Johannes C. Chemische Berichte, 1982 , vol. 115, # 3 p. 860 - 870

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Citation Number: 19

Abstract

... Volume: Page: Digital Object Identifier (DOI). ... Hydrolysis of the aryl esters under basic conditions produced the pyrazole acids 4–7. figure Scheme 1. Synthesis of Pyrazoles 4–7 a. a (a) (OEt) 3 CH, Ac 2 O, 140 °C, 5 h ...