Cardiovascular hybrid drugs: new benzazepinone derivatives as bradycardic agents endowed with selective β 1-non-competitive antagonism
…, F Belluti, P Ioan, E Valoti, A Chiarini, P Valenti
Index: Bisi, Alessandra; Rampa, Angela; Budriesi, Roberta; Gobbi, Silvia; Belluti, Federica; Ioan, Pierfranco; Valoti, Ermanno; Chiarini, Alberto; Valenti, Piero Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1353 - 1361
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Citation Number: 20
Abstract
The synthesis and pharmacological profile of some hybrid compounds bearing both the benzazepinone moiety present in Zatebradine and typical β-blocker aryloxypropanolamine groups are described. The new compounds proved to be endowed with negative chronotropic and inotropic activity and are weak vasorelaxant agents. The cardiodepressant action is probably due to selective β1-noncompetitive reversible antagonism. Both ...
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