Antimalarial drugs. 60. Synthesis, antimalarial activity, and quantitative structure-activity relationships of tebuquine and a series of related 5-[(7-chloro-4-quinolinyl) …

…, JL Johnson, SJ Kesten, DJ McNamara…

Index: Werbel; Cook; Elslager; Hung; Johnson; Kesten; McNamara; Ortwine; Worth Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 924 - 939

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Citation Number: 51

Abstract

A series of 54 (7-chloro-4-quinolinyl) amino]-3-[(alkylamino) methyl][l, l'-biphenyl]-2-ols and N”-oxides was prepared from the substituted 1-phenyl-2-propanones proceeding through the &nitro [l, l'-bipheny1]-2-01~, the corresponding amino, and acetamido derivatives to the N-[5-[(alkylamino) methyl]-6-hydroxy [l, l'-biphenyl]-3-yl] acetamides and final condensation with 4, 7-dichloroquinoline or the N-oxide. In a quantitative structure-activity relationship ...