Canadian Journal of Chemistry

The total synthesis of the cybrodins

WA Ayer, RH McCaskill

Index: Ayer; McCaskill Canadian Journal of Chemistry, 1981 , vol. 59, # 14 p. 2159 - 2169

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Citation Number: 3

Abstract

The total syntheses of cybrodol (1), isocybrodol (2), cybrodal (3), cybrodic acid (4), and trisnorcybrodolide (5), starting from 2-bromomesitylene (6) are described. The route involves oxidation of the 5-methyl group of 6 by means of chromyl acetate, addition of the β-

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