Regioselective synthesis and evaluation of 3-alkylidene-1, 3-dihydroisobenzofurans as potential antidepressant agents
C Praveen, C Iyyappan, K Girija, KS Kumar…
Index: Praveen; Iyyappan; Girija; Kumar, K Suresh; Perumal Journal of Chemical Sciences, 2012 , vol. 124, # 2 p. 451 - 462
Full Text: HTML
Citation Number: 16
Abstract
Abstract 3-Alkylidene-1, 3-dihydroisobenzofurans exhibited moderate antidepressant activity as evaluated by forced swim and tail suspension test methods. Virtual screening was carried out by docking the designed compounds into the serotonin binding sites of arabinase protein to predict the analogue binding mode of the compounds to the SSRIs. Graphical Abstract 3-Alkylidene-1, 3-dihydroisobenzofurans exhibited moderate antidepressant ...
Related Articles:
Free radical-mediated vinyl amination: a mild, general pyrrolidinyl enamine synthesis
[Nugent, Benjamin M.; Williams, Amie L.; Prabhakaran; Johnston, Jeffrey N. Tetrahedron, 2003 , vol. 59, # 45 p. 8877 - 8888]
[Ackermann, Martin; Bucher, Janina; Rappold, Melissa; Graf, Katharina; Rominger, Frank; Hashmi, A. Stephen K. Chemistry - An Asian Journal, 2013 , vol. 8, # 8 p. 1786 - 1794]
Chelation Control through the Coordination of Lewis Acids to an Acetylenic π-Bond
[Asao, Naoki; Asano, Toru; Ohishi, Takeshi; Yamamoto, Yoshinori Journal of the American Chemical Society, 2000 , vol. 122, # 19 p. 4817 - 4818]
Synthesis of biaryls using nickel-catalyzed [2+ 2+ 2] cocyclization
[Sato, Yoshihiro; Ohashi, Kenji; Mori, Miwako Tetrahedron Letters, 1999 , vol. 40, # 28 p. 5231 - 5234]
[Hiroya, Kou; Jouka, Rumi; Kameda, Mitsuyoshi; Yasuhara, Akito; Sakamoto, Takao Tetrahedron, 2001 , vol. 57, # 48 p. 9697 - 9710]