Convenient Synthesis of 1-Oxa-3, 8-diazaspiro [4, 5] Decan-2-ones

R Somanathan, IA Rivero, GI Nuñez…

Index: Somanathan; Rivero; Nunez; Hellberg Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487

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Citation Number: 11

Abstract

R. Somanathan*, LA. Rivero, GI Nuiiez and LH Hellberg. ... Centro de Graduados del lnstituto Tecnologico de Tijuana. Apdo Postal 1166, Tijuana BC MEXICO. ... ABSTRACT: Synthesis of 1 -oxa-3,8-diazospiro [4,5] decan-2- ones from 4-pyridone by addition of trimethylsilyl cyanide. ... Continuing our interest in the synthesis of new antihypertensive agents (l), the syntheses of 9-substituted-1 - oxa -3,8-diazaspiro [4,5]- decan-2-ones reported by Clark and co- ...

Synthesis and antihypertensive activity of a series of 8-substituted 1-oxa-3, 8-diazaspiro [4.5] decan-2-ones

[Caroon; Clark; Kluge; Nelson; Strosberg; Unger; Michel; Whiting Journal of Medicinal Chemistry, 1981 , vol. 24, # 11 p. 1320 - 1328]

Delayed and prolonged histone hyperacetylation with a selective HDAC1/HDAC2 inhibitor

[Methot, Joey L.; Hoffman, Dawn Mampreian; Witter, David J.; Stanton, Matthew G.; Harrington, Paul; Hamblett, Christopher; Siliphaivanh, Phieng; Wilson, Kevin; Hubbs, Jed; Heidebrecht, Richard; Kral, Astrid M.; Ozerova, Nicole; Fleming, Judith C.; Wang, Hongmei; Szewczak, Alexander A.; Middleton, Richard E.; Hughes, Bethany; Cruz, Jonathan C.; Haines, Brian B.; Chenard, Melissa; Kenific, Candia M.; Harsch, Andreas; Secrist, J. Paul; Miller, Thomas A. ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 4 p. 340 - 345]

Delayed and prolonged histone hyperacetylation with a selective HDAC1/HDAC2 inhibitor

Convenient Synthesis of 1-Oxa-3, 8-diazaspiro [4, 5] Decan-2-ones

Abstract

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