Contamination of Dipeptide by Polymer Stabilizers Leached from Gloves and Packaging during Scale-up

…, H Senzaki, T Sugaya, M Kasai

Index: Sano, Takahiro; Senzaki, Hirohiko; Sugaya, Toru; Kasai, Masaji Organic Process Research and Development, 2000 , vol. 4, # 5 p. 349 - 352

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Abstract

In dipeptide production, it was observed that a water solution of a peptide became turbid. The origin of turbidity was monitored and identified by LC-MS analysis. The impurities, derived from natural rubber gloves, and polyethylene bags caused the turbidity when the wet cake of the peptide contacted them.