Aminopyridinecarboxamide-based inhibitors: Structure–activity relationship

…, M Clare, AM Donnelly, JL Glaenzer, JA Guzova…

Index: Bonafoux, Dominique F.; Bonar, Sheri L.; Clare, Michael; Donnelly, Ann M.; Glaenzer, Jeanette L.; Guzova, Julia A.; Huang, He; Kishore, Nandidni N.; Koszyk, Francis J.; Lennon, Patrick J.; Libby, Adam; Mathialagan, Sumathy; Oburn, David S.; Rouw, Sharon A; Sommers, Cynthia D.; Tripp, Catherine S.; Vanella, Lori J.; Weier, Richard; Wolfson, Serge G.; Huang, Horng-Chih Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 1 p. 403 - 414

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Citation Number: 3

Abstract

Series of aminopyridinecarboxamide-based inhibitors were synthesized and tested against human recombinant IKK-2 and in IL-1β stimulated synovial fibroblasts. The 2-amino-5- chloropyridine-4-carboxamides were identified as the most potent inhibitors with improved cellular activity.