Design, synthesis and anticancer activities of diaryl urea derivatives bearing N-acylhydrazone moiety
…, X Zhai, L Wang, J Yang, Z Tan, P Gong
Index: Zhang, Bei; Zhao, Yanfang; Zhai, Xin; Wang, Lihui; Yang, Jingyu; Tan, Zehui; Gong, Ping Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 8 p. 1046 - 1054
Full Text: HTML
Citation Number: 15
Abstract
A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized. All the target compounds were evaluated for their cytotoxic activities in vitro against human lung adenocarcinoma epithelial cell line (A549), human breast cancer cell line (MDA-MB-231) and human leukemia cell line (HL-60) by standard 3-(4, 5- dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Several compounds ( ...
Related Articles:
Active core structure of terfestatin A, a new specific inhibitor of auxin signaling
[Hayashi, Ken-ichiro; Yamazoe, Atsushi; Ishibashi, Yuki; Kusaka, Naoyuki; Oono, Yutaka; Nozaki, Hiroshi Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 9 p. 5331 - 5344]
[Barrero, Alejandro F.; Quilez del Moral, Jose F.; Mar Herrador; Arteaga, Pilar; Cortes, Manuel; Benites, Julio; Rosellon, Antonio Tetrahedron, 2006 , vol. 62, # 25 p. 6012 - 6017]
[Zagol-Ikapitte, Irene; Amarnath, Venkataraman; Bala, Manju; Roberts II, L. Jackson; Oates, John A.; Boutaud, Olivier Chemical Research in Toxicology, 2010 , vol. 23, # 1 p. 240 - 250]