Facile formation of methylenebis (chalcone) s through unprecedented methylenation reaction. Application to antiparasitic and natural product synthesis
M Thévenin, E Mouray, P Grellier…
Index: Thevenin, Marion; Mouray, Elisabeth; Grellier, Philippe; Dubois, Joelle European Journal of Organic Chemistry, 2014 , vol. 2014, # 14 p. 2986 - 2992
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Abstract
Abstract The formation of methylenebis (chalcone) s has been discovered during deprotection with methoxymethyl groups from trihydroxychalcones. Studies on this methylenation reaction led to a mechanism hypothesis that was extended to other chalcones and to dihydrochalcone, acetophenone, benzophenone and flavone derivatives. This new method was applied to the rapid synthesis of natural product piperanduncin C. These ...
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