Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing

…, C Morano, FX Avilés, J Lorenzo, LD Fricker

Index: Tanco, Sebastian; Zhang, Xin; Morano, Cain; Aviles, Francesc Xavier; Lorenzo, Julia; Fricker, Lloyd D. Journal of Biological Chemistry, 2010 , vol. 285, # 24 p. 18385 - 18396

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Citation Number: 27

Abstract

Abstract CPA4 (carboxypeptidase A4) is a member of the metallocarboxypeptidase family. CPA4 was originally found in a screen of mRNAs up-regulated by sodium butyrate-induced differentiation of cancer cells. Further studies suggested a relation between CPA4 and prostate cancer aggressiveness. In the present study, we determined that CPA4 is secreted from cells as a soluble proenzyme (pro-CPA4) that can be activated by endoproteases, ...