Structure–activity studies on diphenylpyrazine derivatives: A novel class of prostacyclin receptor agonists

T Asaki, T Hamamoto, Y Sugiyama, K Kuwano…

Index: Asaki, Tetsuo; Hamamoto, Taisuke; Sugiyama, Yukiteru; Kuwano, Keiichi; Kuwabara, Kenji Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 21 p. 6692 - 6704

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Citation Number: 35

Abstract

To develop nonprostanoid prostacyclin receptor agonists with a high degree of metabolic resistance and an extended duration of action, a novel series of diphenylpyrazine derivatives was synthesized and evaluated for their inhibition of ADP-induced human platelet aggregation. Structure–activity relationship studies on the side chain containing the carboxylic acid moiety of the lead compound 5c showed that the length of the linker and ...