Discovery of 1, 3, 4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression

…, GE Schiltz, H Arrat, K Scheidt, T Siddique

Index: Lukas, Thomas J.; Schiltz, Gary E.; Arrat, Hasan; Scheidt, Karl; Siddique, Teepu Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1532 - 1537

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Citation Number: 4

Abstract

Abstract The treatment of neurodegenerative diseases is difficult because of multiple etiologies and the interplay of genetics and environment as precipitating factors. In the case of amyotrophic lateral sclerosis (ALS), we have knowledge of a handful of genes that cause disease when mutated. However, drugs to counteract the effect of genetic mutations have not yet been found. One of the causative genes, Cu, Zn-superoxide dismutase (SOD1) is ...