Tetrahedron letters

Solid phase synthesis of 2-aminobutadienes using a piperazine linker

NW Hird, K Irie, K Nagai

Index: Hird, Nicholas W.; Irie, Kazuyuki; Nagai, Katsunori Tetrahedron Letters, 1997 , vol. 38, # 40 p. 7111 - 7114

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Citation Number: 47

Abstract

A series of resin-bound 4-substituted-2-aminobutadienes have been synthesised via Wittig reaction with polymer supported 2-(N-piperazino) prop-1-enyl-1-triphenylphosphonium bromide. The use of piperazine provides a readily cleavable enamine linker for attachment of ketones that is compatible with anion chemistry.

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