Stereo??Controlled Asymmetric Bioreduction of α, β??Dehydroamino Acid Derivatives

…, M Bonnekessel, K Zangger, K Faber

Index: Stueckler, Clemens; Winkler, Christoph K.; Hall, Melanie; Hauer, Bernhard; Bonnekessel, Melanie; Zangger, Klaus; Faber, Kurt Advanced Synthesis and Catalysis, 2011 , vol. 353, # 7 p. 1169 - 1173

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Citation Number: 31

Abstract

Abstract α, β-Dehydroamino acid derivatives proved to be a novel substrate class for ene- reductases from the 'old yellow enzyme'(OYE) family. Whereas N-acylamino substituents were tolerated in the α-position, β-analogues were generally unreactive. For aspartic acid derivatives, the stereochemical outcome of the bioreduction using OYE3 could be controlled by variation of the N-acyl protective group to furnish the corresponding (S)-or (R)-amino ...