Improved Chiral Synthesis of Ravuconazole
L Xu, MR Muller, X Yu, BQ Zhu
Index: Xu, Lin; Muller, Marc R.; Yu, Xiong; Zhu, Bao-Quan Synthetic Communications, 2009 , vol. 39, # 9 p. 1611 - 1625
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Citation Number: 7
Abstract
Abstract A short, elegant, and high yielding synthesis of ravoconazole is presented. The key step of this synthesis is an enantioselective palladium-catalyzed chiral zinc-allene addition reaction. The starting materials are 2-chloro-1-(2, 4-difluorophenyl)-ethanone and (R)-4- phenylbutyn-2-ol obtained from enzymatic resolution of its racemate.
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