The process development of ravuconazole: an efficient multikilogram scale preparation of an antifungal agent (1)

…, J Bien, P Brodfuehrer, Y Chan, E Corbett…

Index: Pesti, Jaan; Chen, Chien-Kuang; Spangler, Lori; DelMonte, Albert J.; Benoit, Serge; Berglund, Derek; Xbien, Derek; Brodfuehrer, Paul; Chan, Yeung; Corbett, Elisabeth; Costello, Carrie; DeMena, Paul; Discordia, Robert P.; Doubleday, Wendel; Gao, Zhinong; Gingras, Stephane; Grosso, John; Haas, Oscar; Kacsur, David; Lai, Chiajen; Leung, Simon; Miller, Melanie; Muslehiddinoglu, Jale; Nguyen, Nina; Qiu, Jun; Olzog, Martina; Reiff, Emily; Thoraval, Dominique; Totleben, Michael; Vanyo, Dale; Vemishetti, Purushotham; Wasylak, John; Wei, Chenkou Organic Process Research and Development, 2009 , vol. 13, # 4 p. 716 - 728

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Citation Number: 18

Abstract

The development of a safe, robust process for the preparation of ravuconazole (1), an antifungal agent, is described. The discovery and development of procedures enabling the efficient synthesis of multikilogram quantities of 1 and the process demonstration through plant scale preparations are presented. A controlled means to prepare a Grignard reagent and utilization of Fourier Transform Infrared spectroscopy (FTIR) monitoring to safely ...