Synthesis and biological activities of neurokinin pseudopeptide analogues containing a reduced peptide bond

…, P Schmitt, G Drapeau, D Regoli, R Michelot

Index: Jukic; Mayer; Schmitt; Drapeau; Regoli; Michelot European Journal of Medicinal Chemistry, 1991 , vol. 26, # 9 p. 921 - 928

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Citation Number: 5

Abstract

Abstract A series of pseudopeptides, analogues of neurokinin selective agonists, in which a peptide bond was replaced by a (CH 2 NH) bond were synthesized. The biological activities of these compounds were determined on selective pharmacological preparations: the dog carotid artery for NK-1, the rabbit pulmonary artery devoid of endothelium for the NK-2 and the rat portal vein for the NK-3 receptors. The results reported in this study indicate that ...