Acceptor substrate-based selective inhibition of galactosyltransferases

SJ Chung, S Takayama, CH Wong

Index: Chung, Sang J.; Takayama, Shuichi; Wong, Chi-Huey Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 23 p. 3359 - 3364

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Citation Number: 22

Abstract

This paper describes the discovery of glycosyl acceptor analogs as potent and selective inhibitors of α-1, 3-and β-1, 4-galactosyltransferases. Incorporation of an appropriate aromatic group to the aglycon position of the enzyme's acceptors results in a strong inhibition, representing the first and most potent small uncharged molecules as selective inhibitors of these two enzymes and thus providing a new strategy for the development of ...