Design of N-acetyl-6-sulfo-β-D-glucosaminide-based inhibitors of influenza virus sialidase

…, T Takahashi, T Suzuki, Y Suzuki, K Kobayashi

Index: Sasaki, Kenji; Nishida, Yoshihiro; Kambara, Mikie; Uzawa, Hirotaka; Takahashi, Tadanobu; Suzuki, Takashi; Suzuki, Yasuo; Kobayashi, Kazukiyo Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1367 - 1375

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Citation Number: 17

Abstract

Biological activity of N-acetyl-6-sulfo-β-d-glucosaminides (6-sulfo-GlcNAc 1) having a structural homology to N-acetylneuraminic acid (Neu5Ac 2) and 2-deoxy-2, 3-dehydro-N- acetylneuraminic acid (Neu5Ac2en 3) was examined in terms of inhibitory activity against influenza virus sialidase (influenza, A/Memphis/1/71 H3N2). pNP 6-Sulfo-GlcNAc 1a was proved to show substantial activity to inhibit the virus sialidase (IC50= 2.8 mM), though p- ...