Tetrahedron

An improved and practical synthesis of 5, 5-dimethyl-3-(2-propoxy)-4-(4-methanesulfonylphenyl)-2-(5H)-furanone (DFP—a selective inhibitor of cyclooxygenase-2)

S Padakanti, M Pal, KR Yeleswarapu

Index: Padakanti, Srinivas; Pal, Manojit; Yeleswarapu, Koteswar Rao Tetrahedron, 2003 , vol. 59, # 40 p. 7915 - 7920

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Citation Number: 25

Abstract

DFP [5,5-dimethyl-3-(2-propoxy)-4-(4-methanesulfonylphenyl)-2(5H)-furanone] 1, one of the most selective cyclooxygenase-2 (COX-2) inhibitors recently discovered by Merck, 1 belongs to the 3,4-disubstituted furanone class of compounds that includes rofecoxib 2 2 (Fig. 1). DFP has been shown to be a more potent and more selective inhibitor of COX-2 isozyme than rofecoxib. Cyclooxygenase (COX), the first enzyme involved in the biosynthesis of ...