A general and accurate nmr determination of the enantiomeric purity of α-aminoacids and α-aminoacid derivatives
M Calmes, J Daunis, R Jacquier, J Verducci
Index: Calmes, Monique; Daunis, Jacques; Jacquier, Robert; Verducci, Jean Tetrahedron, 1987 , vol. 43, # 10 p. 2285 - 2292
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Citation Number: 18
Abstract
Derivatization of α-aminoacids, α-aminoesters and α-aminolactones as N-acetyl derivatives allow the accurate NMR determination of the enantiomeric purity. In these conditions the major coordination site with a chiral shift reagent will correspond to the NMR observation site. Experimental factors leading to the highest ΔΔδ values are ascertained. No straightforward correlation with absolute configurations can be established.
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