Chemistry Letters

A convenient method for the synthesis of carboxamides and peptides by the use of tetrabutylammonium salts.

Y Watanabe, T Mukaiyama

Index: Watanabe, Yutaka; Mukaiyama, Teruaki Chemistry Letters, 1981 , p. 285 - 288

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Citation Number: 19

Abstract

Various carboxamides and peptides are prepared in good yields by treatment of free acids and amines in H 2 O-dichloromethane or aqueous THF with bis (o-nitrophenyl) phenylphosphonate in the presence of tetrabutylammonium hydrogen sulfate or bromide. Carboxylic esters are also successfully converted to amides via carboxylate salts in one-pot.

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