Direct Amide Coupling of Non??activated Carboxylic Acids and Amines Catalysed by Zirconium (IV) Chloride

H Lundberg, F Tinnis…

Index: Lundberg, Helena; Tinnis, Fredrik; Adolfsson, Hans Chemistry - A European Journal, 2012 , vol. 18, # 13 p. 3822 - 3826

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Citation Number: 70

Abstract

The amide bond is one of the most important functionalities found in nature. It constitutes the backbone of the biologically crucial peptides and is found in many natural products and the majority of pharmaceutically interesting compounds.[1] It has been estimated that up to 25% of all synthetic pharmaceuticals contain at least one amide bond [2] and a general protocol for the direct amidation of carboxylic acids is highly attractive for industry because it would ...