Thermodynamics and kinetic aspects involved in the enzymatic resolution of (R, S)-3-fluoroalanine in a coupled system of redox reactions catalyzed by …

…, OAC Antunes, EG Oestreicher

Index: Goncalves, Luciana P. B.; Antunes; Oestreicher, Enrique G. Organic Process Research and Development, 2006 , vol. 10, # 3 p. 673 - 677

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Citation Number: 11

Abstract

Two systems of redox enzymatic reactions were tested, looking forward to the preparation of (S)-3-fluoroalanine, a potent antibiotic, by kinetic resolution of rac-3-fluoroalanine. This starting material was the main substrate for the deaminative oxidation reaction catalyzed by l- alanine dehydrogenase (l-AlaDH) in the presence of NAD+. One system was formed by coupling this reaction (main reaction) to the reduction of 3-fluoropyruvate (a cascade ...

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