Palladium-catalyzed cyclocarbonylation of o-iodoanilines with imidoyl chlorides to produce quinazolin-4 (3H)-ones
Z Zheng, H Alper
Index: Zheng, Zhaoyan; Alper, Howard Organic Letters, 2008 , vol. 10, # 5 p. 829 - 832
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Citation Number: 78
Abstract
A wide variety of substituted quinazolin-4 (3H)-ones were prepared in 63-91% yields by the palladium-catalyzed cyclocarbonylation of o-iodoanilines with imidoyl chlorides and carbon monoxide. The reaction is believed to proceed via in situ formation of an amidine, followed by oxidative addition, CO insertion, and intramolecular cyclization to give the substituted quinazolin-4 (3H)-ones.
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