The Journal of organic chemistry

Quinazolines and 1, 4-benzodiazepines. 77. Reaction of 2-amino-1, 4-benzodiazepines with bifunctional acylating agents

RI Fryer, JV Earley, JF Blount

Index: Fryer,R.I. et al. Journal of Organic Chemistry, 1977 , vol. 42, p. 2212 - 2219

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Citation Number: 10

Abstract

8 rn-ClPBA= m-chloroperbenzoic acid oxide derivative 3 gave a mixture of two products, compounds 4 and 5, both of which, while containing the anticipated new ring formed between the 1 and 2 positions of the benzodiazepine ring, were further modified as indicated by the structures shown. Treatment of the 3-acetoxy benzodiazepine 6 under the same conditions also gave a mixture of two products, compounds 5 and 7.