Synthesis and structure-activity relationships among. alpha.-adrenergic receptor agonists of the phenylethanolamine type

…, JC Bizec, N Bieth, J Schwartz

Index: Leclerc, Gerard; Bizec, Jean Claude; Bieth, Nicole; Schwartz, Jean Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 738 - 744

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Citation Number: 15

Abstract

I have shown that the phenolic hydroxy groups can be replaced by the acidic alkyl or arylsulfonamide substituents (soterenol, IC) or similar groups (carbuterol, ld) without altering the a and/? activities. However, a catechol-like function is certainly not an indispensable feature, since high/?-adrenergic activity can be exhibited by 3, 5-dihydroxy derivatives (terbutaline, le)