Enzymatic nitrile hydrolysis catalyzed by nitrilase ZmNIT2 from maize. An unprecedented β-hydroxy functionality enhanced amide formation
C Mukherjee, D Zhu, ER Biehl, RR Parmar, L Hua
Index: Mukherjee, Chandrani; Zhu, Dunming; Biehl, Edward R.; Parmar, Rajiv R.; Hua, Ling Tetrahedron, 2006 , vol. 62, # 26 p. 6150 - 6154
Full Text: HTML
Citation Number: 22
Abstract
To explore the synthetic potential of nitrilase ZmNIT2 from maize, the substrate specificity of this nitrilase was studied with a diverse collection of nitriles. The nitrilase ZmNIT2 showed high activity for all the tested nitriles except benzonitrile, producing both acids and amides. For the hydrolysis of aliphatic, aromatic nitriles, phenylacetonitrile derivatives and dinitriles, carboxylic acids were the major products. Unexpectedly, amides were found to be the ...
Related Articles:
Amides from nitriles using basic hydrogen peroxide under phase-transfer catalysed conditions
[Cacchi, S.; Misiti, D.; Torre, F. La Synthesis, 1980 , # 3 p. 243 - 244]
The Willgerodt Reaction. II. A Study of Reaction Conditions with Acetophenone and Other Ketones1, 2
[De Tar; Carmack Journal of the American Chemical Society, 1946 , vol. 68, p. 2025,2028]
[Freudenreich, Charles; Samama, Jean-Pierre; Biellmann, Jean-Francois Journal of the American Chemical Society, 1984 , vol. 106, # 11 p. 3344 - 3353]
Intramolecular aryl transfer to thionium ions in an approach to α-arylacetamides
[Ovens, Caroline; Vogel, Johannes C.; Martin, Nathaniel G.; Procter, David J. Chemical Communications, 2009 , # 21 p. 3101 - 3103]
[Salauen, Arnaud; Favre, Annaick; Le Grel, Barbara; Potel, Michel; Le Grel, Philippe Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 150 - 158]