Design of inhibitors from the three-dimensional structure of alcohol dehydrogenase. Chemical synthesis and enzymic properties

C Freudenreich, JP Samama…

Index: Freudenreich, Charles; Samama, Jean-Pierre; Biellmann, Jean-Francois Journal of the American Chemical Society, 1984 , vol. 106, # 11 p. 3344 - 3353

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Citation Number: 38

Abstract

Abstract: Inhibitors of liver alcohol dehydrogenase were designed from the three- dimensional structure of the enzyme. The ligand to t: ie catalytic zinc ion is an amide group or, better, a formamide group. With the latter function, a hydrogen bond between thc NH group and the hydroxyl group of Ser-48 may be formed. The hydrophobic substrate binding site brings structural restraints. a--w bifunctional molecules show good inhibitory ...