Synthesis of Highly Substituted Oxazoles through Iodine (III)-Mediated Reactions of Ketones with Nitriles
A Saito, N Hyodo, Y Hanzawa
Index: Saito, Akio; Hyodo, Nao; Hanzawa, Yuji Molecules, 2012 , vol. 17, # 9 p. 11046 - 11055
Full Text: HTML
Citation Number: 10
Abstract
Abstract In the presence of trifluoromethanesulfonic acid (TfOH) or bis (trifluoromethane- sulfonyl) imide (Tf 2 NH), iodosobenzene (PhI= O) efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2, 4- disubstituted and 2, 4, 5-trisubstituted oxazole in a single step under the mild conditions. Keywords:
Related Articles:
[Doyle, Michael P.; Buhro, William E.; Davidson, James G.; Elliott, Robert C.; Hoekstra, James W.; Oppenhuizen, Mark Journal of Organic Chemistry, 1980 , vol. 45, # 18 p. 3657 - 3664]
Various oxidative reactions with novel ion-supported (diacetoxyiodo) benzenes
[Iinuma, Masataka; Moriyama, Katsuhiko; Togo, Hideo Tetrahedron, 2013 , vol. 69, # 14 p. 2961 - 2970]
[Schuh, Kerstin; Glorius, Frank Synthesis, 2007 , # 15 p. 2297 - 2306]
Rapid synthesis of oxazoles under microwave conditions
[Brain, Christopher T.; Paul, Jane M. Synlett, 1999 , # 10 p. 1642 - 1644]
Catalytic Reactions of Carbene Precursors on Bulk Gold Metal
[Zhou, Yibo; Trewyn, Brian G.; Angelici, Robert J.; Woo, L. Keith Journal of the American Chemical Society, 2009 , vol. 131, # 33 p. 11734 - 11743]