Chemistry Letters

Radical-mediated carbonylation of alkyl iodides in aqueous media

M Sugiura, H Hagio, S Kobayashi

Index: Sugiura, Masaharu; Hagio, Hiroyuki; Kobayashi, Shu Chemistry Letters, 2003 , vol. 32, # 10 p. 898 - 899

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Citation Number: 14

Abstract

Radical-mediated single carbonylation of alkyl iodides furnishing carboxylic acids proceeded in water using phosphinic acid as a radical initiator in the presence of a surfactant (CTAB). On the other hand, formation of double carbonylation product (α-keto carboxylic acid) along with single carbonylation product was observed for the first time, when the reaction was carried out in aqueous ethanol without any surfactants.