Synthesis and Biological Evaluation of New Quinoxaline Derivatives as Antioxidant and Anti??Inflammatory Agents

…, D Hadjipavlou??Litina, S Ancizu, R Villar…

Index: Burguete, Asuncion; Pontiki, Eleni; Hadjipavlou-Litina, Dimitra; Ancizu, Saioa; Villar, Raquel; Solano, Beatriz; Moreno, Elsa; Torres, Enrique; Perez, Silvia; Aldana, Ignacio; Monge, Antonio Chemical Biology and Drug Design, 2011 , vol. 77, # 4 p. 255 - 267

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Citation Number: 30

Abstract

We report the synthesis, anti-inflammatory, and antioxidant activities of novel quinoxaline and quinoxaline 1, 4-di-N-oxide derivatives. Microwaveassisted methods have been used to optimize reaction times and to improve yields. The tested compounds presented important scavenging activities and promising in vitro inhibition of soybean lipoxygenase (LOX). Two of the best LOX inhibitors (compounds 7b and 8f) were evaluated as in vivo anti- ...