An improved and efficient Synthesis of Quinoxalinecarboxamide 1, 4??Dioxides from benzofuroxan and acetoacetamides in the presence of calcium salts
G Stumm, HJ Niclas
Index: Stumm, G.; Niclas, H.-J. Journal fuer Praktische Chemie (Leipzig), 1989 , vol. 331, # 5 p. 736 - 744
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Citation Number: 16
Abstract
Abstract An improved and efficient method for the preparation of the title compounds 3 is described. Thus, quinoxalinecarboxamide 1, 4-dioxides 3 are synthesized in high yields by reaction of benzofuroxan 1 with acetoacetamides 2 in the presence of catalytic amounts of calcium salts and ethanolamine. The reaction is assumed to involve a chelate mechanism with 4 as intermediate. Side reactions are studied by means of HPLC and TLC.
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