Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of 3, 5-dimethyl pyrazoles, 3-methyl pyrazol-5-ones and 3, 5-disubstituted …
M Amir, S Kumar
Index: Amir, Mohd; Kumar, Shikha Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 12 p. 2532 - 2537
Full Text: HTML
Citation Number: 98
Abstract
Abstract: 3, 5-Dimethyl pyrazole 3a-d and 3-methyl pyrazol-5-one 4a-d derivatives of diclofenac, ibuprofen, flurbiprofen and 2, 4-dichlorophenoxy acetic acid have been synthesized. In addition, substituted pyrazoline derivatives of ibuprofen 6a-e have also been prepared by treating different chalcones 5a-e with ibuprofen hydrazide. Some of the newly synthesized compounds are screened for anti-inflammatory activity and few compounds ...
Related Articles:
[Verma, Anil K.; Koul, Summon; Pannu, Ajay P.S.; Razdan, Tej K. Tetrahedron, 2007 , vol. 63, # 36 p. 8715 - 8722]
Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1)
[Ma, Lei; Yang, Zhengyi; Li, Chenjing; Zhu, Zhiyuan; Shen, Xu; Hu, Lihong Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 5 p. 643 - 648]
Hydration of the flavylium ion
[Journal of the American Chemical Society, , vol. 102, # 18 p. 5838 - 5848]
Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1)
[Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 26, # 5 p. 643 - 648]
Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1)
[Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 26, # 5 p. 643 - 648]